The Plymouth Fire Department responded to the request for mutual aid by the Argos Fire Department on Sunday afternoon.
About 4:30 firefighters from Plymouth responded to a call of a structure fire at 10777 14C Road.
As firefighters arrived on the scene the home was a blaze with black smoke raising high into the sky.
Details have not been release but Plymouth firefighters were on the scene for a couple of hours.
The home sustained major damage from the fire, smoke and water.
Argos firefighters were called back to the scene about 9:30 Sunday evening as the fire had rekindled.